HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Slonim, A. E Search for Related Content PubMed Articles by Slonim, A. E Agricola Articles by Slonim, A. E

Skeletal Muscle Metabolism In Exercise and Diabetes

North Shore University Hospital 300 Community Drive Manhasset, NY 11030 E-mail: slonim{at}nsuh.edu

Skeletal Muscle Metabolism In Exercise and Diabetes edited by Erik A Richter, Bente Kiens, Henrik Galbo, and Bengt Saltin, 1998, 328 pages, hardcover. Plenum Publishing, New York.

This book is a superb compilation of the most up-to-date information on muscle metabolism during exercise. It will be particularly informative for those readers who are interested in understanding the mechanism of transport and metabolism of macronutrients during exercise in normal subjects as well as in disease states such as diabetes and obesity. It is a compendium of the presentations at the Symposium on Skeletal Muscle Metabolism in Exercise held at the Copenhagen Muscle Research Center in October of 1997.

The volume consists of 28 chapters and covers most of the important aspects of muscle energy metabolism that relate to exercise. The emphasis is on the regulation of glucose and fatty acid uptake, transport, and metabolism, culminating in their use as individual fuels, as well as how these macronutrients affect the metabolism of the other macronutrients during exercise. The chapters are contributed by world experts in their fields and are concise and well edited and include helpful, adequate references. The first half of the book is devoted to glucose metabolism, the second half to fatty acid metabolism, with several chapters that interrelate fat and carbohydrate metabolism in muscle. The last 2 chapters are devoted to amino acid metabolism in muscle during exercise.

The chapters are logically arranged, starting with an overview of glucose uptake, followed by the anatomy of glucose transporters, the role of transverse tubules, and glucose transporter proteins in glucose uptake into muscle. The similar but independent action of insulin stimulation and muscle contraction on glucose transport into skeletal muscle is discussed, as well as their effects on the development of the insulin-resistant state and of type 2 diabetes and obesity. Chapters are allotted to the role of nitric oxide, adenosine, and exercise training in muscle glucose transport.

Similarly to the in-depth analysis of glucose metabolism, factors that control fatty acid metabolism during exercise are discussed. Lipolysis, fatty acid delivery, transport of long-chain fatty acids across the muscular endothelium, muscle fatty acid transporters, and intracellular transport of fatty acids in muscle are each given a chapter. The effect of exercise training on fatty acid uptake, metabolism, and oxidation are discussed. Two particularly pertinent chapters, on the action of malonyl-CoA as a regulator of insulin sensitivity and anaplerosis of the tricarboxylic acid cycle, incorporate much of the information of the preceding chapters to explain how these 2 principal muscle nutrients are integrated and utilized as fuels by skeletal muscle during exercise.

If there is a criticism of this volume, it is for the paucity of discussion on the uptake and metabolism of amino acids during exercise, even with 2 excellent chapters contributed by Rennie and Wagenmakers. Amino acids are usually not used as fuels during moderate exercise in normal subjects, but as has been pointed out by Wagenmakers, in certain metabolic muscle disorders or prolonged fasting, the inability to utilize either glycogen or fatty acids results in utilization of alternative fuels, including amino acids, during exercise.

In summary, this is an excellent book that will provide those dealing with the subject of exercise and nutrition an in-depth understanding of the underlying mechanisms by which the fuels of the body are transported and metabolized and ultimately produce the critical energy required to initiate and maintain muscle exercise and prevent fatigue.

This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Slonim, A. E Search for Related Content PubMed Articles by Slonim, A. E Agricola Articles by Slonim, A. E