| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Discipline of Obstetrics and Gynaecology (Research Centre for Reproductive Health), School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia (LJM, RJN, and MN); the Department of Medicine, University of Adelaide, Adelaide, Australia (GAW); and Human Nutrition, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide, Australia (LJM, MN, PMC, and GW)
Background: Polycystic ovary syndrome (PCOS), a common condition in women, improves with weight loss. Meal replacements in short-term weight loss and strategies for weight maintenance have not been investigated in PCOS.
Objective: We compared in overweight women with PCOS the effects of meal replacements in short-term weight-loss and longer-term carbohydrate- or fat-restriction strategies on weight maintenance and improvements in reproductive and metabolic variables.
Design: Overweight women with PCOS (n = 43; 
± SD age: 32.1 ± 5.2 y; weight: 96.1 ± 18.4 kg) followed an 8-wk weight-loss regimen (2 meal replacements/d, 4904.4 ± 127 kJ; phase 1) and then a 6-mo weight-maintenance carbohydrate- (<120 g/d) or fat- (<50 g/d) restriction regimen (phase 2).
Results: Thirty-four women completed phase 1, and 23 women completed phase 2; the proportion of dropouts was similar in the 2 groups. During phase 1, significant (P < 0.05) reductions in weight (5.6 ± 2.4 kg), waist circumference (6.1 ± 2.5 cm), body fat (4.1 ± 2.2 kg), insulin (2.8 ± 1.1 mU/L), total testosterone (0.3 ± 0.7 nmol/L), and free androgen index (3.1 ± 4.6) occurred; these changes were sustained during phase 2. No significant differences between diet groups were seen for any variables. At 6 mo, both approaches resulted in a net weight loss of 4.7 ± 4.6 kg. Improvements in menstrual cyclicity occurred for 16 (57.1%) of 28 subjects.
Conclusions: Meal replacements are an effective strategy for the short-term management of PCOS. Advice on moderate fat or carbohydrate restriction was equally effective in maintaining weight reduction and improving reproductive and metabolic variables.
Key Words: Polycystic ovary syndrome • weight loss • weight maintenance • glycemic index • meal replacement
This article has been cited by other articles:
|
|
 |
|
  L. J Moran, M. Noakes, P. M Clifton, G. A Wittert, C. W Le Roux, M. A Ghatei, S. R Bloom, and R. J Norman Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1603 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Moran, M. Noakes, P. M. Clifton, and R. J. Norman The Use of Anti-Mullerian Hormone in Predicting Menstrual Response after Weight Loss in Overweight Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3796 - 3802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, D. P. Belobrajdic, and R. J. Norman C-Reactive Protein before and after Weight Loss in Overweight Women with and without Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 2944 - 2951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Legro A 27-Year-Old Woman With a Diagnosis of Polycystic Ovary Syndrome JAMA, February 7, 2007; 297(5): 509 - 519. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
