| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Clinic of Endocrinology, University Hospital MAS, Malmö, Sweden (AHF); the Department of Applied Nutrition and Food Chemistry, Lund University, Lund, Sweden (MN and IMEB); and the Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark (JJH)
Background:Whey proteins have insulinotropic effects and reduce the postprandial glycemia in healthy subjects. The mechanism is not known, but insulinogenic amino acids and the incretin hormones seem to be involved.
Objective:The aim was to evaluate whether supplementation of meals with a high glycemic index (GI) with whey proteins may increase insulin secretion and improve blood glucose control in type 2 diabetic subjects.
Design:Fourteen diet-treated subjects with type 2 diabetes were served a high-GI breakfast (white bread) and subsequent high-GI lunch (mashed potatoes with meatballs). The breakfast and lunch meals were supplemented with whey on one day; whey was exchanged for lean ham and lactose on another day. Venous blood samples were drawn before and during 4 h after breakfast and 3 h after lunch for the measurement of blood glucose, serum insulin, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide 1 (GLP-1).
Results:The insulin responses were higher after both breakfast (31%) and lunch (57%) when whey was included in the meal than when whey was not included. After lunch, the blood glucose response was significantly reduced [–21%; 120 min area under the curve (AUC)] after whey ingestion. Postprandial GIP responses were higher after whey ingestion, whereas no differences were found in GLP-1 between the reference and test meals.
Conclusions:It can be concluded that the addition of whey to meals with rapidly digested and absorbed carbohydrates stimulates insulin release and reduces postprandial blood glucose excursion after a lunch meal consisting of mashed potatoes and meatballs in type 2 diabetic subjects.
Key Words: Milk • whey • type 2 diabetes • blood glucose • serum insulin • incretin hormones
This article has been cited by other articles:
|
|
 |
|
  J. Bao, V. de Jong, F. Atkinson, P. Petocz, and J. C Brand-Miller Food insulin index: physiologic basis for predicting insulin demand evoked by composite meals Am. J. Clinical Nutrition, October 1, 2009; 90(4): 986 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S Mortensen, M. L Hartvigsen, L. J Brader, A. Astrup, J. Schrezenmeir, J. J Holst, C. Thomsen, and K. Hermansen Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein Am. J. Clinical Nutrition, July 1, 2009; 90(1): 41 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Vanschoonbeek, M. Lansink, K. M. J. van Laere, J. M. G. Senden, L. B. Verdijk, and L. J. C. van Loon Slowly Digestible Carbohydrate Sources Can Be Used to Attenuate the Postprandial Glycemic Response to the Ingestion of Diabetes-Specific Enteral Formulas The Diabetes Educator, July 1, 2009; 35(4): 631 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Rusu, R. Drouin, Y. Pouliot, S. Gauthier, and P. E. Poubelle A Bovine Whey Protein Extract Can Enhance Innate Immunity by Priming Normal Human Blood Neutrophils J. Nutr., February 1, 2009; 139(2): 386 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Hoppe, G. S. Andersen, S. Jacobsen, C. Molgaard, H. Friis, P. T. Sangild, and K. F. Michaelsen The Use of Whey or Skimmed Milk Powder in Fortified Blended Foods for Vulnerable Groups J. Nutr., January 1, 2008; 138(1): 145S - 161S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Luhovyy, T. Akhavan, and G. H. Anderson Whey Proteins in the Regulation of Food Intake and Satiety J. Am. Coll. Nutr., December 1, 2007; 26(6): 704S - 712S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Krissansen Emerging Health Properties of Whey Proteins and Their Clinical Implications J. Am. Coll. Nutr., December 1, 2007; 26(6): 713S - 723S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Karamanlis, R. Chaikomin, S. Doran, M. Bellon, F D. Bartholomeusz, J. M Wishart, K. L Jones, M. Horowitz, and C. K Rayner Effects of protein on glycemic and incretin responses and gastric emptying after oral glucose in healthy subjects Am. J. Clinical Nutrition, November 1, 2007; 86(5): 1364 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sieri, V. Pala, F. Brighenti, N. Pellegrini, P. Muti, A. Micheli, A. Evangelista, S. Grioni, P. Contiero, F. Berrino, et al. Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian prospective cohort study Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1160 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Amano, M. Sugiyama, J. S. Lee, K. Kawakubo, K. Mori, A. C. Tang, and A. Akabayashi Glycemic Index-Based Nutritional Education Improves Blood Glucose Control in Japanese Adults: A randomized controlled trial Diabetes Care, July 1, 2007; 30(7): 1874 - 1876. [Full Text] [PDF]
|
|
|
|
|
|
S. E Kasim-Karakas, W. M Cunningham, and A. Tsodikov Relation of nutrients and hormones in polycystic ovary syndrome Am. J. Clinical Nutrition, March 1, 2007; 85(3): 688 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J.F. Manders, S. F.E. Praet, R. C.R. Meex, R. Koopman, A. L. de Roos, A. J.M. Wagenmakers, W. H.M. Saris, and L. J.C. van Loon Protein Hydrolysate/Leucine Co-Ingestion Reduces the Prevalence of Hyperglycemia in Type 2 Diabetic Patients Diabetes Care, December 1, 2006; 29(12): 2721 - 2722. [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Drucker Enhancing the action of incretin hormones: a new whey forward? Endocrinology, July 1, 2006; 147(7): 3171 - 3172. [Full Text] [PDF]
|
|
|
|
|
|
P. T. Gunnarsson, M. S. Winzell, C. F. Deacon, M. O. Larsen, K. Jelic, R. D. Carr, and B. Ahren Glucose-Induced Incretin Hormone Release and Inactivation Are Differently Modulated by Oral Fat and Protein in Mice Endocrinology, July 1, 2006; 147(7): 3173 - 3180. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
