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American Journal of Clinical Nutrition, Vol 8, 812-816, Copyright © 1960 by The American Society for Clinical Nutrition, Inc.

Excretion of Urinary Metabolites in Calcium Oxalate Urolithiasis

Effect of Tryptophan and Vitamin B6 Administration

STANLEY N. GERSHOFF PH.D.1, EDWIN L. PRIEN M.D.1, FAROUK F. FARAGALLA 1, GRACE S. H. SHEN 1, and MARY M. KEARNEY 1

1 From the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Studies of the urinary excretion of a number of metabolites by normal adults and by persons suffering from chronic formation of calcium oxalate calculi have been made. The normal subjects excreted significantly less xanthurenic acid and 4-pyridoxic acid and more citric acid than the patients.

Following administration of tryptophan, there was a marked rise in the excretion of oxalate. In all but two of the subjects, ingestion of vitamin B6 was followed by a decrease in urinary oxalate.






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Copyright © 1960 by The American Society for Nutrition