HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cunnane, S. C Articles by Jenkins, D. J. Search for Related Content PubMed PubMed Citation Articles by Cunnane, S. C Articles by Jenkins, D. J. Agricola Articles by Cunnane, S. C Articles by Jenkins, D. J.

ß-Oxidation of linoleate in obese men undergoing weight loss^1,2,3

¹ From the Department of Nutritional Sciences, Faculty of Medicine, University of Toronto; the Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto; the School of Physical and Health Education, Queen's University, Kingston, Canada; and the Risk Factor Modification Center, St Michael's Hospital, Toronto.

Background: In animals, the whole-body content and accumulation of linoleate can be measured and compared with its intake to determine linoleate ß-oxidation. This method can also provide quantitative information about the ß-oxidation of linoleate in humans.

Objectives: The objectives of the study were to 1) use the wholebody fatty acid balance method to quantify whole-body concentrations of linoleate in humans, 2) estimate the distribution of linoleate between adipose and lean tissue, and 3) assess the effect of weight loss on linoleate stores and ß-oxidation in obese humans.

Design: Nine healthy obese men underwent supervised weight loss for 112 d (16 wk). Magnetic resonance imaging data and fatty acid profiles from fat biopsies were both used to determine linoleate stores in adipose and lean tissue and in the whole body. Linoleate ß-oxidation was calculated as intake - (accumulation + excretion).

Results: Mean weight loss was 13 kg and linoleate intake was 24 ± 6 mmol/d over the study period. Whole-body loss of linoleate was 37 ± 18 mmol/d, or 28% of the level before weight loss. Combining the intake and whole-body loss of linoleate resulted in linoleate ß-oxidation exceeding intake by 2.5-fold during the weight-loss period.

Conclusions: All dietary linoleate is ß-oxidized and at least an equivalent amount of linoleate is lost from the body during moderate weight loss in obese men. The method studied permits the assessment of long-term changes in linoleate homeostasis in obese humans and may be useful in determining the risk of linoleate deficiency in other conditions.

Key Words: Adipose tissue • linoleate • magnetic resonance imaging • obesity • weight loss • exercise • ß-oxidation

This article has been cited by other articles:

				U. McCloy, M. A. Ryan, P. B. Pencharz, R. J. Ross, and S. C. Cunnane A comparison of the metabolism of eighteen-carbon 13C-unsaturated fatty acids in healthy women J. Lipid Res., March 1, 2004; 45(3): 474 - 485. [Abstract] [Full Text] [PDF]