American Journal of Clinical Nutrition, Vol 62, 1096S-1100S, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Control of energy intake by energy metabolism

MI Friedman
Monell Chemical Senses Center, Philadelphia, PA 19104-3308, USA.

Eating behavior is controlled by signals that are generated in the postabsorptive metabolism of energy-yielding substrates. Recent work indicates that an event common to the metabolism of glucose and fat provides such a signal. Evidence suggests that eating behavior is triggered by a signal that is tied to hepatic ATP concentrations and is carried from the liver to brain via afferents in the vagus nerve. This metabolic control of eating behavior may link mechanisms of energy storage and expenditure to energy intake. Changes in energy intake associated with alterations in energy expenditure can be viewed as a response to a shift in the partitioning of fuels, which affects the oxidative metabolic pathways that generate the signal controlling eating behavior.

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