| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 62, 458S-462S, Copyright © 1995 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
B Paigen
Jackson Laboratory, Bar Harbor, ME 04609, USA.
The natural variation among inbred strains of mice was used to elucidate the genetic factors underlying the responsiveness to high-fat and high-cholesterol diets. The nine strains examined are the progenitors of recombinant inbred strain sets: C57BL/6J, C57L/J, SWR/J, SJL/J, SM/J, A/J, AKR/J, C3H/HeJ, and DBA/2J. Plasma lipids, liver lipids, the prevalence of cholesterol gallstones, and the size of aortic fatty streak lesions were examined after 18 wk of consumption of the diet containing 15% fat and 1% cholesterol. The variation in aortic lesions found among inbred strains provided the basis for several additional studies that demonstrated the existence of eight genes affecting atherosclerosis. These genes, named Ath1 to Ath8, are briefly described. The genetic analysis of variation in gallstone formation demonstrated that more than one gene affects this phenotype.
This article has been cited by other articles:
|
|
 |
|
  G. S. Getz and C. A. Reardon Diet and Murine Atherosclerosis Arterioscler. Thromb. Vasc. Biol., February 1, 2006; 26(2): 242 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Teupser, M. Tan, A. D. Persky, and J. L. Breslow Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice PNAS, January 3, 2006; 103(1): 123 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Allayee, A. Ghazalpour, and A. J. Lusis Using Mice to Dissect Genetic Factors in Atherosclerosis Arterioscler. Thromb. Vasc. Biol., September 1, 2003; 23(9): 1501 - 1509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Kulkarni, K. Almind, H. J. Goren, J. N. Winnay, K. Ueki, T. Okada, and C. R. Kahn Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice Diabetes, June 1, 2003; 52(6): 1528 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang and B. Paigen Comparative Genetics of Atherosclerosis and Restenosis: Exploration With Mouse Models Arterioscler. Thromb. Vasc. Biol., June 1, 2002; 22(6): 884 - 886. [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Pitman, R. Korstanje, G. A. Churchill, E. Nicodeme, J. J. Albers, M. C. Cheung, M. A. Staton, S. S. Sampson, S. Harris, and B. Paigen Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice Physiol Genomics, May 10, 2002; 9(2): 93 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lu, M.-H. Lee, H. Yu, Y. Zhou, S. A. Sandell, G. Salen, and S. B. Patel Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8 J. Lipid Res., April 1, 2002; 43(4): 565 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Dansky, P. Shu, M. Donavan, J. Montagno, D. L. Nagle, J. S. Smutko, N. Roy, S. Whiteing, J. Barrios, T. J. McBride, et al. A Phenotype-Sensitizing Apoe-Deficient Genetic Background Reveals Novel Atherosclerosis Predisposition Loci in the Mouse Genetics, April 1, 2002; 160(4): 1599 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Silence, F. Lupu, D. Collen, and H. R. Lijnen Persistence of Atherosclerotic Plaque but Reduced Aneurysm Formation in Mice With Stromelysin-1 (MMP-3) Gene Inactivation Arterioscler. Thromb. Vasc. Biol., September 1, 2001; 21(9): 1440 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Welch, S. Bretschger, N. Latib, M. Bezouevski, Y. Guo, N. Pleskac, C.-P. Liang, C. Barlow, H. Dansky, J. L. Breslow, et al. Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model PNAS, July 3, 2001; 98(14): 7946 - 7951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Souidi, M. Combettes-Souverain, F. Milliat, E. R. Eckhardt, O. Audas, S. Dubrac, M. Parquet, J. Férézou, and C. Lutton Hamsters Predisposed to Sucrose-Induced Cholesterol Gallstones (LPN Strain) Are More Resistant to Excess Dietary Cholesterol than Hamsters That Are Not Sensitive to Cholelithiasis Induction J. Nutr., June 1, 2001; 131(6): 1803 - 1811. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Ishimori, K. Iwabuchi, S. Fujii, K. Watano, C. Iwabuchi, M. Ato, H. Chiba, S. Tanaka, A. Kitabatake, and K. Onoé Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice J. Leukoc. Biol., May 1, 2001; 69(5): 732 - 740. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. L. Breslow Genetic Differences in Endothelial Cells May Determine Atherosclerosis Susceptibility Circulation, July 4, 2000; 102(1): 5 - 6. [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Rader and E. Pure Genetic Susceptibility to Atherosclerosis : Insights From Mice Circ. Res., May 26, 2000; 86(10): 1013 - 1015. [Full Text] [PDF]
|
|
|
|
|
|
A. Mouzeyan, J. Choi, H. Allayee, X. Wang, J. Sinsheimer, J. Phan, L. W. Castellani, K. Reue, A. J. Lusis, and R. C. Davis A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2 J. Lipid Res., April 1, 2000; 41(4): 573 - 582. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. P. Didion, C. D. Sigmund, F. M. Faraci, and Z. S. Katusic Impaired Endothelial Function in Transgenic Mice Expressing Both Human Renin and Human Angiotensinogen • Editorial Comment Stroke, March 1, 2000; 31(3): 760 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Lijnen, P. Soloway, and D. Collen Tissue Inhibitor of Matrix Metalloproteinases-1 Impairs Arterial Neointima Formation After Vascular Injury in Mice Circ. Res., December 3, 1999; 85(12): 1186 - 1191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Lijnen, B. Van Hoef, I. Vanlinthout, M. Verstreken, M.-C. Rio, and D. Collen Accelerated Neointima Formation After Vascular Injury in Mice With Stromelysin-3 (MMP-11) Gene Inactivation Arterioscler. Thromb. Vasc. Biol., December 1, 1999; 19(12): 2863 - 2870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Jolley, J. M. Dietschy, and S. D. Turley Genetic differences in cholesterol absorption in 129/Sv and C57BL/6 mice: effect on cholesterol responsiveness Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1117 - G1124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tall, C. Welch, D. Applebaum-Bowden, and M. Wassef Interaction of Diet and Genes in Atherogenesis Report of an NHLBI Working Group Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 3326 - 3331. [Abstract] [Full Text]
|
|
|
|
|
|
M. F. Nageh, E. T. Sandberg, K. R. Marotti, A. H. Lin, E. P. Melchior, D. C. Bullard, and A. L. Beaudet Deficiency of Inflammatory Cell Adhesion Molecules Protects Against Atherosclerosis in Mice Arterioscler. Thromb. Vasc. Biol., August 1, 1997; 17(8): 1517 - 1520. [Abstract] [Full Text]
|
|
|
|
|
|
C. P. Carter, P. N. Howles, and D. Y. Hui Genetic Variation in Cholesterol Absorption Efficiency among Inbred Strains of Mice J. Nutr., July 1, 1997; 127(7): 1344 - 1348. [Abstract] [Full Text]
|
|
|
|
|
|
J. Silence, D. Collen, and H.R. Lijnen Reduced Atherosclerotic Plaque but Enhanced Aneurysm Formation in Mice With Inactivation of the Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Gene Circ. Res., May 3, 2002; 90(8): 897 - 903. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
