AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Klein, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klein, G. L.
Agricola
Right arrow Articles by Klein, G. L.

American Journal of Clinical Nutrition, Vol 61, 449-456, Copyright © 1995 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Aluminum in parenteral solutions revisited--again

GL Klein
Department of Pediatrics, University of Texas Medical Branch, Galveston.

It has been a dozen years since aluminum was first shown to contaminate parenteral nutrition solutions and to be a contributing factor in the pathogenesis of metabolic bone disease in parenteral nutrition patients as well as in uremic patients. However, there are no regulations in place to effectively reduce aluminum contamination of various parenterally administered nutrients, drugs, and biologic products. The purpose of this review is fourfold: 1) to summarize our knowledge of the adverse effects of aluminum on bone formation and mineralization in parenteral nutrition patients; 2) to discuss the possible role of aluminum in the osteopenic bone disease of preterm infants; 3) to show how lack of regulations covering aluminum content of parenteral solutions can lead to vulnerability of new groups of patients to aluminum toxicity, the example being given here is that of burn patients; and 4) to trace the development of efforts at regulating the aluminum contamination of large- and small-volume parenteral drug products and to point out what still needs to be done in this regard.


This article has been cited by other articles:


Home page
 The Annals of PharmacotherapyHome page
R. O Brown, L. M Morgan, S. K Bhattacharya, P. L Johnson, G. Minard, and R. N Dickerson
Potential Aluminum Exposure from Parenteral Nutrition in Patients with Acute Kidney Injury
Ann. Pharmacother., October 1, 2008; 42(10): 1410 - 1415.
[Abstract] [Full Text] [PDF]

Home page
 Am J Health Syst PharmHome page
R. A. Speerhas and D. L. Seidner
Measured versus estimated aluminum content of parenteral nutrient solutions
Am. J. Health Syst. Pharm., April 1, 2007; 64(7): 740 - 746.
[Abstract] [Full Text] [PDF]

Home page
 Am J Health Syst PharmHome page
T. W. Canada
Aluminum exposure through parenteral nutrition formulations: Mathematical versus clinical relevance
Am. J. Health Syst. Pharm., February 1, 2005; 62(3): 315 - 318.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by The American Society for Nutrition