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American Journal of Clinical Nutrition, Vol 59, 654-658, Copyright © 1994 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Copper deficiency affects selenoglutathione peroxidase and selenodeiodinase activities and antioxidant defense in weanling rats

KL Olin, RM Walter and CL Keen
Department of Nutrition, University of California, Davis 95616-8669.

Copper deficiency has been postulated result in low selenoglutathione peroxidase (Se-GSHPx) activity, secondary to alterations in the antioxidant defense system. Type I iodothyronine 5'-deiodinase contains selenium; because it is not part of the antioxidant defense system its measurement provides a way to evaluate the influence of copper on selenoenzymes independent of the antioxidant system. Weanling rats were fed the control diet (125.9 nmol Cu/g diet), copper-deficient diet (7.9 nmol Cu/g diet), or the control diet restricted to the intake of the deficient rats (restrict-fed), for 21 d. Rats fed the copper-deficient diet had cardiomegaly, low hematocrit values, and low tissue copper concentrations, but normal liver selenium concentrations. Liver and plasma Se-GSHPx activities were lowest in the deficient rats. Non-Se- GSHPx activity was similar between control and copper-deficient groups. Liver selenodeiodinase activity was lowest in the copper-deficient rats; this reduction was functionally significant as evidenced by low plasma 3,3',5-triiodothyronine and high plasma 3,3',5'-triiodothyronine concentrations.


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Copyright © 1994 by The American Society for Nutrition