American Journal of Clinical Nutrition, Vol 51, 399-406, Copyright © 1990 by The American Society for Clinical Nutrition, Inc

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Fish oils in hypertriglyceridemia: a dose-response study

WS Harris, DW Rothrock, A Fanning, SB Inkeles, SH Goodnight Jr, DR Illingworth and WE Connor
Division of Endocrinology, Metabolism and Clinical Nutrition, Oregon Health Sciences University, Portland.

The effects of three supplemental doses of fish oil on plasma lipids, lipoproteins, and bleeding times were studied in ten hypertriglyceridemic patients. After a 3-wk baseline period each patient was given 15, 25, or 40 mL fish oil/d (containing 4.5, 7.5, and 12 g n-3 fatty acids) for three successive 6-wk periods, each separated by a 4-wk period of no supplementation. Plasma cholesterol concentrations decreased from 7.40 mmol/L to 6.35, 6.55, and 6.40 mmol/L with increasing doses of fish oil (p less than 0.01 vs baseline for each). Plasma triglyceride concentrations decreased from 6.10 mmol/L to 2.90, 2.80, and 2.35 mmol/L (p less than 0.01 vs baseline for each). Low-density-lipoprotein cholesterol concentrations increased significantly (by 23% and 28%) with the two higher doses, respectively. Bleeding times increased only with the largest dose. The lowest dose was the most hypolipidemic per gram n-3 fatty acids.

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				References Circulation, December 17, 2002; 106(25): 3373 - 3421. [Full Text]