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American Journal of Clinical Nutrition, Vol 51, 80-86, Copyright © 1990 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Evaluation of the deoxyuridine suppression test by using whole blood samples from folic acid-supplemented subjects

T Tamura, SJ Soong, HE Sauberlich, KD Hatch, P Cole and CE Butterworth Jr
Department of Nutrition Sciences, University of Alabama, Birmingham 35294.

We performed the deoxyuridine suppression test (dUST) along with assessment of folate and vitamin B-12 status in blood specimens from 136 normal women and 109 women with cervical dysplasia. All tests were repeated at 2, 4, and 6 mo in subjects with dysplasia during a randomized, double-blind intervention trial in which 50 received a 10- mg daily oral folic acid supplement (F group) and 59 received a placebo (P group). Median folate concentration increased fivefold in plasma and threefold in erythrocytes of F group beginning at the second months and remained elevated whereas concentrations of the P group remained unchanged. Vitamin B-12 values did not vary significantly in either group. The dUST value decreased from 10.4 +/- 4.6% (means +/- SD) pretreatment to 4.5 +/- 4.7% in F group after 2 mo (p less than 0.001). The dUST values had significant negative correlation with plasma and erythrocyte folate concentrations. However, erythrocyte folate had the greatest power to distinguish P group from F group.


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J. F. Gregory III, J. Williamson, L. B. Bailey, and J. P. Toth
Urinary Excretion of [2H4]Folate by Nonpregnant Women Following a Single Oral Dose of [2H4]Folic Acid Is a Functional Index of Folate Nutritional Status
J. Nutr., November 1, 1998; 128(11): 1907 - 1912.
[Abstract] [Full Text]


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Copyright © 1990 by The American Society for Nutrition