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American Journal of Clinical Nutrition, Vol 50, 504-507, Copyright © 1989 by The American Society for Clinical Nutrition, Inc


ORIGINAL RESEARCH COMMUNICATIONS

Blood carnitine status after orthotopic liver transplantation in patients with end-stage liver disease

JD Palombo, PR Borum, RL Jenkins, C Trey and BR Bistrian
Laboratory of Nutrition/Infection, New England Deaconess Hospital/Harvard Medical School, Boston, MA 02215.

We determined the effects of orthotopic liver transplantation on plasma and red cell carnitine concentrations in patients with end-stage liver disease. Before transplantation, plasma and red cell carnitine were significantly elevated above normal. The partitioning factor (ratio of red cell carnitine to plasma carnitine) was four times greater than that observed in our reference population. After hepatic replacement, plasma and red cell carnitine approached normal levels within 6 mo. The partitioning factor, however, remained elevated at that time. These results indicate that 1) there is no evidence for carnitine deficiency in severe liver disease on the basis of carnitine concentrations in the plasma and red compartments and 2) altered partitioning of carnitine between plasma and red cells persists for greater than or equal to 6 mo after hepatic replacement.


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[Abstract] [PDF]




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Copyright © 1989 by The American Society for Nutrition