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American Journal of Clinical Nutrition, Vol 49, 44-50, Copyright © 1989 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers

AG Dulloo, CA Geissler, T Horton, A Collins and DS Miller
Department of Nutrition, King's College, University of London, UK.

Single-dose oral administration of 100 mg caffeine increased the resting metabolic rate of both lean and postobese human volunteers by 3- 4% (p less than 0.02) over 150 min and improved the defective diet- induced thermogenesis observed in the postobese subjects. Measurements of energy expenditure (EE) in a room respirometer indicate that repeated caffeine administration (100 mg) at 2-h intervals over a 12-h day period increased the EE of both subject groups by 8-11% (p less than 0.01) during that period but had no influence on the subsequent 12- h night EE. The net effect was a significant increase (p less than 0.02) in daily EE of 150 kcal in the lean volunteers and 79 kcal in the postobese subjects. Caffeine at commonly consumed doses can have a significant influence on energy balance and may promote thermogenesis in the treatment of obesity.


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