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American Journal of Clinical Nutrition, Vol 48, 1284-1290, Copyright © 1988 by The American Society for Clinical Nutrition, Inc


ORIGINAL RESEARCH COMMUNICATIONS

Effect of age on changes in plasma, erythrocyte, and urinary B-6 vitamers after an oral vitamin B-6 load

AK Kant, PB Moser-Veillon and RD Reynolds
Department of Food, Nutrition and Institution Administration, University of Maryland, College Park, MD 20742.

We investigated the effect of age on indices of vitamin B-6 metabolism in 36 fasting males aged 25-35, 45-55, and 65-75 y who ingested 17.15 mumol vitamin B-6. There were no significant differences among groups in dietary vitamin B-6 intake, base-line erythrocyte pyridoxal 5'- phosphate (PLP), and total vitamin B-6 concentrations, and 24-h and base-line urinary excretion of total vitamin B-6 and 4-pyridoxic acid (4-PA). Base-line plasma PLP and total vitamin B-6 were higher (p less than 0.05) in the youngest group. Increased serum alkaline phosphatase (AP) and decreased dietary vitamin B-6 intake were correlated with decreased base-line plasma PLP and total vitamin B-6. Changes in plasma and erythrocyte PLP concentrations and excretion of 4-PA and total vitamin B-6 postload were not different among groups. Indices of vitamin B-6 absorption, phosphorylation, and excretion were not affected by age.


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M. V. Bor, H. Refsum, M. R. Bisp, O. Bleie, J. Schneede, J. E. Nordrehaug, P. M. Ueland, O. K. Nygard, and E. Nexo
Plasma Vitamin B6 Vitamers before and after Oral Vitamin B6 Treatment: A Randomized Placebo-controlled Study
Clin. Chem., January 1, 2003; 49(1): 155 - 161.
[Abstract] [Full Text] [PDF]




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Copyright © 1988 by The American Society for Nutrition