American Journal of Clinical Nutrition, Vol 48, 775-779, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Role of dietary factors in cell replication and colon cancer

R Jacobs
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048.

Human studies and experimental data from animals suggest that high rates of colonic epithelial cell replication enhance the development of colon cancer. Vegetarians and individuals following a prudent diet have lower rates of colorectal cell proliferation than subjects at high risk for colon cancer. Animal studies show that colonic cell proliferation is stimulated by feeding in general and specifically by a number of dietary fibers, fats, bile acids, and short-chain fatty acids. Many of these growth factors also increase the induction of experimental tumorigenesis. On the other hand factors that reduce cell growth, including ascorbic acid and butylated hydroxyanisole, inhibit colon carcinogenesis. These results support the concept that dietary chemoprevention is feasible and could significantly reduce the rate of colon cancer development in high risk populations.

This article has been cited by other articles:

				J. T. Wu, S. Y. Archer, B. Hinnebusch, S. Meng, and R. A. Hodin Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis Am J Physiol Gastrointest Liver Physiol, March 1, 2001; 280(3): G482 - G490. [Abstract] [Full Text] [PDF]

				A L Hubbard, D J Harrison, C Moyes, A H Wyllie, C Cunningham, E Mannion, and C A D Smith N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions Gut, August 1, 1997; 41(2): 229 - 234. [Abstract] [Full Text] [PDF]