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American Journal of Clinical Nutrition, Vol 47, 875-878, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Impression cytology detects subclinical vitamin A deficiency

O Amedee-Manesme, R Luzeau, JR Wittepen, A Hanck and A Sommer
Unite de recherche d'Hepatologie infantile, Institut National de la Sante et de la Recherche Medicale (INSERM) U56, Le Kremlin-Bicetre, France.

The vitamin A status of 16 children with normal eyes and liver disease was evaluated by plasma retinol concentration and by liver vitamin A concentration or iv relative-dose-response test. Conjunctival impression cytology was performed on each child. All children with normal vitamin A status had normal conjunctival impression cytology. All children with abnormal vitamin A status had abnormal conjunctival impression cytology despite their seemingly normal clinical ocular examination. These results suggest that impression cytology can identify individuals with physiologically significant, preclinical vitamin A deficiency.


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Copyright © 1988 by The American Society for Nutrition