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American Journal of Clinical Nutrition, Vol 47, 690-693, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Short- and long-term vitamin A treatment in children with cholestasis

O Amedee-Manesme, MS Mourey, J Therasse, M Couturier, F Alvarez, A Hanck and O Bernard
Departement de Pediatrie, Hopital de Bicetre, Le Kremlin, France.

Newborns have limited reserve supplies of vitamin A. Infants with chronic cholestasis are in a precarious nutritional state because of their limited ability to build these stores even though the vitamin is present in their diet. In this study, we investigated liver concentrations of vitamin A in 30 children with extrahepatic biliary atresia. We demonstrate that correction of the deficiency occurs after intramuscular administration of a water-miscible solution of retinyl palmitate (100,000 IU, or 30 mg retinol equivalent). Furthermore, we evaluated the effect of vitamin A injections on liver and blood concentrations in nine children with chronic cholestasis over a 1-y period. We conclude this treatment is efficient and is well tolerated.




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Copyright © 1988 by The American Society for Nutrition