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American Journal of Clinical Nutrition, Vol 47, 400-405, Copyright © 1988 by The American Society for Clinical Nutrition, Inc


ORIGINAL RESEARCH COMMUNICATIONS

Effect of different caloric loads in human jejunum on meal-stimulated and nonstimulated biliopancreatic secretion

N Vidon, A Pfeiffer, C Franchisseur, M Bovet, M Rongier and JJ Bernier
Unite de Recherches sur la Physiopathologie de la Digestion (INSERM U54), Hopital Saint Lazare, Paris, France.

The effects on biliopancreatic secretion of two caloric loads (1.3 and 3.3 kcal/min of Realmentyl: proteins 18%, lipids 27%, carbohydrates 55%), infused into the jejuna of 10 healthy men, were compared with those of a control solution. In one set of experiments (six subjects) when biliopancreatic secretion was not stimulated before infusion, the rate 1.3 kcal/min resulted in mild stimulation whereas the rate 3.3 kcal/min brought about an inhibition of biliopancreatic secretion. In another set of experiments (six subjects) when biliopancreatic secretion was stimulated by ingestion of an homogenized meal (400 mL, 490 kcal) 1 h before the start of infusion, both loads resulted in strong inhibition of pancreatic secretions, the effect being more pronounced with the high caloric load.


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Gut, July 1, 2005; 54(suppl_6): 1 - 28.
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