AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koo, S. I.
Right arrow Articles by Lee, C. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koo, S. I.
Right arrow Articles by Lee, C. C.
Agricola
Right arrow Articles by Koo, S. I.
Right arrow Articles by Lee, C. C.

American Journal of Clinical Nutrition, Vol 47, 120-127, Copyright © 1988 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Compositional changes in plasma high-density lipoprotein particles in marginally zinc-deficient male rats

SI Koo and CC Lee
Department of Biochemistry, Oral Roberts University School of Medicine, Tulsa, OK 74171.

This study investigated the effect of zinc status on the lipid and apolipoprotein composition of high-density lipoproteins (HDL) in adult male rats fed a semipurified diet containing a marginal level (2.8 mg/kg) of Zn as compared with the pair-fed and ad libitum-fed controls given an adequate level (30.8 mg/kg) of Zn for 7-10 wk. Compositional and chromatographic analysis of HDL fraction showed that Zn deficiency significantly lowered the total amount of circulating HDL particles with no effect on the concentrations of total protein, triglyceride, phospholipid, and cholesterol. The ratios of free: esterified cholesterol remained the same for the three groups. Electrophoretic analysis of the apolipoprotein profile showed marked decreases in the relative contents of apolipoproteins E and C and an increase in apolipoprotein (apo) A-I with no significant change in apo A-VI. No apparent morphologic aberrations of HDL particles were observed. Such changes may significantly influence the transport and metabolism of cholesterol and may provide an explanation for altered cholesterol homeostasis in Zn deficiency.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
L. Cui, N. W. Schoene, L. Zhu, J. C. Fanzo, A. Alshatwi, and K. Y. Lei
Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells
Am J Physiol Cell Physiol, August 1, 2002; 283(2): C623 - C630.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. K. Reaves, J. C. Fanzo, J. Y. J. Wu, Y. R. Wang, Y. W. Wu, L. Zhu, and K. Y. Lei
Plasma Apolipoprotein B-48, Hepatic Apolipoprotein B mRNA Editing and Apolipoprotein B mRNA Editing Catalytic Subunit-1 mRNA Levels Are Altered in Zinc-Deficient Rats
J. Nutr., October 1, 1999; 129(10): 1855 - 1861.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Y. J. Wu, Y. Wu, S. K. Reaves, Y. R. Wang, P. P. Lei, and K. Y. Lei
Apolipoprotein A-I gene expression is regulated by cellular zinc status in Hep G2 cells
Am J Physiol Cell Physiol, September 1, 1999; 277(3): C537 - C544.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Y. J. Wu, S. K. Reaves, Y. R. Wang, Y. Wu, P. P. Lei, and K. Y. Lei
Zinc deficiency decreases plasma level and hepatic mRNA abundance of apolipoprotein A-I in rats and hamsters
Am J Physiol Cell Physiol, December 1, 1998; 275(6): C1516 - C1525.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by The American Society for Nutrition