AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Berkelhammer, C. H.
Right arrow Articles by Wolman, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berkelhammer, C. H.
Right arrow Articles by Wolman, S. L.
Agricola
Right arrow Articles by Berkelhammer, C. H.
Right arrow Articles by Wolman, S. L.

American Journal of Clinical Nutrition, Vol 46, 778-783, Copyright © 1987 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Whole-body protein turnover in adult hemodialysis patients as measured by 13C-leucine

CH Berkelhammer, JP Baker, LA Leiter, PR Uldall, R Whittall, A Slater and SL Wolman
Department of Medicine, University of Toronto, Ontario, Canada.

Muscle wasting may occur in patients with chronic renal failure (CRF). To determine whether this is due to a decrease in the synthesis or an increase in the breakdown of muscle protein, we evaluated postabsorptive whole-body protein breakdown, oxidation, and synthesis rates at steady state during a primed, continuous infusion of 13C- leucine. This was done in seven subjects on chronic maintenance hemodialysis (MHD) and in seven normal control subjects. The protein breakdown rate in MHD was not different from that in controls (103 +/- 19 and 106 +/- 19 mumol leucine.kg-1.h-1, respectively). In MHD, however, the protein oxidation rate was 43% greater than that in controls (20 +/- 6 and 14 +/- 4 mumol leucine.kg-1.h-1, p less than 0.05), whereas net protein synthesis was less (p less than 0.05). Reduced net synthesis and increased oxidation rates of protein in the postabsorptive state may therefore contribute to the muscle-wasting syndrome in patients with CRF.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. S. C. Raj, O. Adeniyi, E. A. Dominic, M. A. Boivin, S. McClelland, A. H. Tzamaloukas, N. Morgan, L. Gonzales, R. Wolfe, and A. Ferrando
Amino acid repletion does not decrease muscle protein catabolism during hemodialysis
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1534 - E1542.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. S. C. Raj, P. Zager, V. O. Shah, E. A. Dominic, O. Adeniyi, P. Blandon, R. Wolfe, and A. Ferrando
Protein turnover and amino acid transport kinetics in end-stage renal disease
Am J Physiol Endocrinol Metab, January 1, 2004; 286(1): E136 - E143.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Veeneman, H. A. Kingma, T. S. Boer, F. Stellaard, P. E. De Jong, D.-J. Reijngoud, and R. M. Huisman
Protein intake during hemodialysis maintains a positive whole body protein balance in chronic hemodialysis patients
Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E954 - E965.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. GIORDANO, P. D. FEO, P. LUCIDI, E. dePASCALE, G. GIORDANO, L. INFANTONE, A. M. ZOCCOLO, and P. CASTELLINO
Increased Albumin and Fibrinogen Synthesis in Hemodialysis Patients with Normal Nutritional Status
J. Am. Soc. Nephrol., February 1, 2001; 12(2): 349 - 354.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by The American Society for Nutrition