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American Journal of Clinical Nutrition, Vol 44, 670-677, Copyright © 1986 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of zinc deficiency on mucosal hyperplasia following 70% bowel resection

JA Vanderhoof, JH Park and CJ Grandjean

We evaluated the effect of zinc deficiency on the development of mucosal hyperplasia in male Sprague-Dawley rats following 70% small- bowel resection: 20 underwent 70% jejunoileal resection, another 20 were sham operated. Half of each group were made zinc deficient by force-feeding technique. Operations were then performed, and feedings were continued for another 9 days. While mucosal weight did not differ between zinc-deficient and zinc-replete animals, whether or not they underwent resection, mucosal protein and DNA levels were decreased in both resected and sham-operated, zinc-deficient animals. Functional indices were also affected. Maltase activities were decreased in zinc- deficient animals in the midileum. Mucosal zinc-dependent enzymes, alkaline phosphatase and leucine aminopeptidase, were likewise depressed in zinc-deficient animals. Findings suggest that zinc deficiency in short-bowel syndrome will likely impair mucosal hyperplasia.


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