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American Journal of Clinical Nutrition, Vol 42, 1175-1178, Copyright © 1985 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of butorphanol tartrate on food and water consumption in humans

JE Morley, S Parker and AS Levine

There is much evidence that endogenous opioid peptides are involved in the regulation of food and water intake in a variety of species. We report here that the exogenous opiate agonist, butorphanol tartrate (1 microgram/kg), significantly increases food, but not water, intake in normal humans. The major effect on food intake was seen within the first 2 h after the administration of drug. These findings suggest that this drug may be therapeutically useful in patients with cancer anorexia.




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Copyright © 1985 by The American Society for Nutrition