American Journal of Clinical Nutrition, Vol 35, 678-682, Copyright © 1982 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Enhanced thermogenesis and diminished deposition of fat in response to overfeeding with diet containing medium chain triglyceride

N Baba, EF Bracco and SA Hashim

The mechanism whereby overfeeding with diet containing medium chain triglyceride (MCT) results in diminished body weight and fat was studied. Fifteen male Sprague-Dawley rats were fitted under anesthesia with gastrostomy tubes and divided into two groups. One group was fed MCT diet, the other an isocaloric diet containing long chain triglyceride (LCT) in excess (150%) of spontaneous calorie intake. Both diets, fed for 6 wk, derived 50% of calories from fat. Basal and norepinephrine (25 micrograms/100 g) stimulated 02 consumption and CO2 production, as well as metabolic rate were measured. After the rats were killed, total dissectible fat and fat cell size and number were determined. MCT rats gained 15% less weight than LCT controls (p less than 0.001). Total dissectible fat was significantly lower (p less than 0.001) in MCT group, as was mean adipocyte size (p less than 0.001). Resting and maximal norepinephrine-stimulated 02 consumptions were 39.7 and 22.1% higher in MCT than in LCT group, respectively. Resting and norepinephrine-stimulated metabolic rates were 38.8 and 22.2% higher in MCT than LCT fed rats, respectively. Overfeeding MCT diet results in decreased body fat related to increased metabolic rate and thermogenesis.

This article has been cited by other articles:

				M. Newell-McGloughlin Nutritionally Improved Agricultural Crops Plant Physiology, July 1, 2008; 147(3): 939 - 953. [Full Text] [PDF]

				M.-P. St-Onge and A. Bosarge Weight-loss diet that includes consumption of medium-chain triacylglycerol oil leads to a greater rate of weight and fat mass loss than does olive oil Am. J. Clinical Nutrition, March 1, 2008; 87(3): 621 - 626. [Abstract] [Full Text] [PDF]

				M.-P. St-Onge, B. Lamarche, J.-F. Mauger, and P. J. H. Jones Consumption of a Functional Oil Rich in Phytosterols and Medium-Chain Triglyceride Oil Improves Plasma Lipid Profiles in Men J. Nutr., June 1, 2003; 133(6): 1815 - 1820. [Abstract] [Full Text] [PDF]

				M D. Robertson, K. G Jackson, B. A Fielding, L. M Morgan, C. M Williams, and K. N Frayn Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans Am. J. Clinical Nutrition, July 1, 2002; 76(1): 232 - 238. [Abstract] [Full Text] [PDF]

				M.-P. St-Onge and P. J. H. Jones Physiological Effects of Medium-Chain Triglycerides: Potential Agents in the Prevention of Obesity J. Nutr., March 1, 2002; 132(3): 329 - 332. [Abstract] [Full Text] [PDF]

				H. Tsuji, M. Kasai, H. Takeuchi, M. Nakamura, M. Okazaki, and K. Kondo Dietary Medium-Chain Triacylglycerols Suppress Accumulation of Body Fat in a Double-Blind, Controlled Trial in Healthy Men and Women J. Nutr., November 1, 2001; 131(11): 2853 - 2859. [Abstract] [Full Text] [PDF]

				M. M. Gottschlich Invited Review: Selection of Optimal Lipid Sources in Enteral and Parenteral Nutrition Nutr Clin Pract, August 1, 1992; 7(4): 152 - 165. [Abstract] [PDF]