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American Journal of Clinical Nutrition, Vol 35, 50-55, Copyright © 1982 by The American Society for Nutrition

The effect of diet on daily D-glucaric acid excretion in young men

Phyllis E. Bowen Ph.D.1, Nga Hong Nguyen M.S.1, and Forrest W. Thye Ph.D.1

1 From the Department of Human Nutrition and Foods, Virginia Polytechnic Institute and State University, Blacksburg, VA.

Increased urinary excretion of D-glucaric acid may be a useful indicator of the induction of enzymes connected with the metabolism of drugs and other nonnutrient substances. The effect of diet on the variability of daily D-glucaric acid excretion was assessed in 16 young men who consumed freely-selected diets for 7 days, a single-menu diet for 10 days and a chemically defined diet for 7 days. Ten subjects remained on the chemically defined diet. No difference in either the variability or the group mean excretion was found between any of the diets although some individuals altered their excretion with dietary change. A limit for D-glucaric acid excretion in the "noninduced state" was set at 32.6 µmol D-glucaric acid/24 h for this group. Afternoon casual urine samples correlated more closely than morning samples with an individual's full-day excretion. Correlations between casual and full-day samples were too low on self-selected diets to use for individual screening purposes although casual sample group means approximated daily group means.

Key Words: Saccharic acid • D-glucaric acid • drug metabolism • xenobiotics • mixed-function oxidase system • monooxygenase system • diet • microsomal drug metabolizing system

Submitted on December 19, 1980
Accepted on July 17, 1981






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Copyright © 1982 by The American Society for Nutrition