AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gordon, P. R.
Right arrow Articles by O'Dell, B. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gordon, P. R.
Right arrow Articles by O'Dell, B. L.
Agricola
Right arrow Articles by Gordon, P. R.
Right arrow Articles by O'Dell, B. L.

American Journal of Clinical Nutrition, Vol 35, 113-119, Copyright © 1982 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of acute zinc deprivation on plasma zinc and platelet aggregation in adult males

PR Gordon, CW Woodruff, HL Anderson and BL O'Dell

In view of earlier results obtained with rodents, the present study was designed to investigate the effect of acute zinc deprivation in man on plasma zinc concentration and the response of platelets to aggregating agents. Three adult men consumed a formula diet based largely on soybean protein for 12 to 14 days. During the control period the diet was supplemented with 12 mg zinc per day. Without supplementation the diet supplied approximately 0.5 mg zinc per 3.0 Mcal; it contained 0.7 ppm zinc, and 0.2% phytate. After removal of the zinc supplement plasma zinc dropped rapidly and reached a minimum by the 5th day. There was a wide diurnal variation in plasma zinc concentration in one subject with the overnight fasting value being the highest and decreasing soon after the morning meal. Platelet aggregation in response to ADP and arachidonate was impaired when plasma zinc was 60 micrograms/dl or less and was restored to normal within 19 h of oral zinc supplementation. These results demonstrate that plasma zinc can be rapidly decreased by dietary zinc deprivation and that extracellular zinc plays an important role in platelet aggregation.


This article has been cited by other articles:


Home page
 J. Am. Coll. Nutr.Home page
J. Arnaud, M. Bost, D. Vitoux, J. Labarere, P. Galan, H. Faure, S. Hercberg, J.-C. Bordet, A.-M. Roussel, and P. Chappuis
Effect of Low Dose Antioxidant Vitamin and Trace Element Supplementation on the Urinary Concentrations of Thromboxane and Prostacyclin Metabolites
J. Am. Coll. Nutr., October 1, 2007; 26(5): 405 - 411.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
S. Hughes and S. Samman
The effect of zinc supplementation in humans on plasma lipids, antioxidant status and thrombogenesis.
J. Am. Coll. Nutr., August 1, 2006; 25(4): 285 - 291.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by The American Society for Nutrition