American Journal of Clinical Nutrition, Vol 34, 1779-1784, Copyright © 1981 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Acute effects of increased meat protein on urinary electrolytes and cyclic adenosine monophosphate and serum parathyroid hormone

AA Licata

The effect of a high meat protein diet on urinary electrolytes, cyclic AMP, and serum immunoassayable parathyroid hormone was studied in six subjects fed a high meat protein diet (1.5 to 2.9 g/kg) for 7 days. The diet produced minor decreases in serum calcium and phosphorus but increased endogenous creatinine clearance by about 20% (p less than 0.02) and urinary calcium by about 80% (p less than 0.01) without changing urinary sodium. Urinary calcium correlated (p less than 0.01) with urinary sulfate (r = 0.60), ammonia (r = 0.72), and nitrogen (r = 0.60). Urinary cyclic AMP increased (p less than 0.01) 14% while serum parathyroid hormone (measured by C-terminal assays) decreased (p less than 0.05) by more than 30%. It was concluded 1) that this diet acutely altered renal handling of calcium at a site different from that of sodium, 2) that the excretion of acidic products of protein metabolism contributed to these changes, and 3) that parathyroid hormone secretion was not changed acutely.

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