AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Corrigan, J. J.
Right arrow Articles by Ulfers, L. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Corrigan, J. J., Jr
Right arrow Articles by Ulfers, L. L.
Agricola
Right arrow Articles by Corrigan, J. J.
Right arrow Articles by Ulfers, L. L.

American Journal of Clinical Nutrition, Vol 34, 1701-1705, Copyright © 1981 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency

JJ Corrigan Jr and LL Ulfers

Rats rendered lightly vitamin K deficient with warfarin (0.01 mg/100 g, IP) and given the equivalent of 1000 units of vitamin E/kg IM for 7 days, showed a marked reduction in functional factor II activity, but normal factor II levels using Echis venom on coagulation analysis. In 12 humans receiving warfarin, vitamin E was administered in doses of 100 or 400 units/day orally for 4 wk. The results in these patients showed no significant change in the prothrombin time, factor II coagulant activity, or factor II antigen (by electroimmunoassay). However, by using a ratio of factor II coagulant activity to immunoreactive protein, significant reduction was observed when compared to pretreatment ratios. These data suggest that vitamin E acts at the step mediated by vitamin K and not in the synthesis of the factor II precursor. Although the administration of high doses of vitamin E in animals, and possibly humans, with vitamin K deficiency potentiates the vitamin K deficiency, this effect is not clinically obvious with 400 IU/day or less.


This article has been cited by other articles:


Home page
 NEJMHome page
A. R. Rumbold, C. A. Crowther, R. R. Haslam, G. A. Dekker, J. S. Robinson, and the ACTS Study Group
Vitamins C and E and the risks of preeclampsia and perinatal complications.
N. Engl. J. Med., April 27, 2006; 354(17): 1796 - 1806.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
A. H. Lichtenstein and R. M. Russell
Essential Nutrients: Food or Supplements?: Where Should the Emphasis Be?
JAMA, July 20, 2005; 294(3): 351 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. L Booth, I. Golly, J. M Sacheck, R. Roubenoff, G. E Dallal, K. Hamada, and J. B Blumberg
Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status
Am. J. Clinical Nutrition, July 1, 2004; 80(1): 143 - 148.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by The American Society for Nutrition