AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wheby, M. S.
Right arrow Articles by Spyker, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wheby, M. S.
Right arrow Articles by Spyker, D. A.
Agricola
Right arrow Articles by Wheby, M. S.
Right arrow Articles by Spyker, D. A.

American Journal of Clinical Nutrition, Vol 34, 1686-1693, Copyright © 1981 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Hemoglobin iron absorption kinetics in the iron-deficient dog

MS Wheby and DA Spyker

In the absorption of Hb iron (HbFe), heme is separated from globin in the intestinal lumen and enters mucosal cells where Fe is split off and transported to blood. Previous studies indicated that this final step is the limiting one in absorption of HbFe in normal and Fe loaded animals but not in Fe-deficient animals. The present studies were designed to determine the limiting step in absorption of HbFe in Fe- deficient dogs. Varying Amounts of 59Fe labeled Hb were injected into closed duodenal loops in anesthetized dogs. Each step in the absorptive process was measured: intralumenal separation of the heme from Hb; mucosal uptake of heme; intramucosal splitting of Fe from heme; transport of Fe to blood. This process was characterized using a five compartment kinetic model. The resulting seven rate constants were determined to best describe the observed absorption data. Results show: 1) with increasing dose of 59HbFe, mucosal uptake of heme, Fe split from heme in mucosa, and Fe transported to blood all increase linearly. 2) Mucosal 59Fe-heme accumulates over the 3-hour period while 59Fe does not, indicating rapid transport of 59Fe split from heme. These results suggest that the rate limiting step in absorption of HbFe in Fe- deficient dogs is the splitting of Fe from heme in the mucosa.


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
T. A. Markel, P. R. Crisostomo, M. Wang, C. M. Herring, K. K. Meldrum, K. D. Lillemoe, and D. R. Meldrum
The struggle for iron: gastrointestinal microbes modulate the host immune response during infection
J. Leukoc. Biol., February 1, 2007; 81(2): 393 - 400.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
F. Pizarro, M. Olivares, E. Hertrampf, D. I. Mazariegos, and M. Arredondo
Heme-Iron Absorption Is Saturable by Heme-Iron Dose in Women
J. Nutr., July 1, 2003; 133(7): 2214 - 2217.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by The American Society for Nutrition