AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hershko, C.
Right arrow Articles by Izak, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hershko, C.
Right arrow Articles by Izak, G.
Agricola
Right arrow Articles by Hershko, C.
Right arrow Articles by Izak, G.

American Journal of Clinical Nutrition, Vol 34, 1600-1610, Copyright © 1981 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Diagnosis of iron deficiency anemia in a rural population of children. Relative usefulness of serum ferritin, red cell protoporphyrin, red cell indices, and transferrin saturation determinations

C Hershko, D Bar-Or, Y Gaziel, E Naparstek, AM Konijn, N Grossowicz, N Kaufman and G Izak

The diagnostic usefulness in iron deficiency anemia of serum ferritin, red cell protoporphyrin (Epp), mean corpuscular volume, mean corpuscular hemoglobin (MCH), and transferrin saturation measurements has been studied in a population of 294 children aged 1 to 6 yr. Of the children studied 19% had hemoglobin below 11 g/dl. Iron deficiency, diagnosed by at least two abnormal independent laboratory parameters, was the cause of anemia in all except two cases. The Pearson correlation coefficient for hemoglobin was highest with MCH, followed in decreasing order of magnitude by MCV, Epp, transferrin saturation, and finally by ferritin. Sensitivity and specificity were highest for MCH and lowest for ferritin. Of anemic, iron deficient individuals 97 to 100% could be identified by low MCH, 88 to 100% by transferrin saturation, 66 to 83% by ferritin, and 61 to 74% by Epp. In contrast, only 0 to 6% of normal, nonanemic individuals had low MCH, 0 to 4% had high Epp, but 21 to 39% had low transferrin saturation and 25 to 39% had low ferritin. Although reduced serum ferritin in anemic individuals is good evidence of iron deficiency, a significant proportion of anemic iron-deficient patients is missed by this procedure rendering it less useful than other, less expensive laboratory methods.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
A. B. Perez-Exposito, S. Villalpando, J. A. Rivera, I. J. Griffin, and S. A. Abrams
Ferrous Sulfate Is More Bioavailable among Preschoolers than Other Forms of Iron in a Milk-Based Weaning Food Distributed by PROGRESA, a National Program in Mexico
J. Nutr., January 1, 2005; 135(1): 64 - 69.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
R. M. Siegel and D. H. LaGrone
The Use of Zinc Protoporphyrin in Screening Young Children for Iron Deficiency
Clinical Pediatrics, August 1, 1994; 33(8): 473 - 479.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by The American Society for Nutrition