American Journal of Clinical Nutrition, Vol 34, 305-311, Copyright © 1981 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Urinary oxalate excretion after large intakes of ascorbic acid in man

KH Schmidt, V Hagmaier, DH Hornig, JP Vuilleumier and G Rutishauser

The influence of high dose intake of ascorbic acid on the urinary excretion of oxalate was investigated in five healthy male volunteers. Oxalate was measured by a newly developed specific method using isotachophoresis. With intakes of 10 g ascorbic acid (5 X 2 g daily for 5 days; four subjects) mean urinary oxalate excretion was enhanced from about 50 mg to 87 mg (range 60 to 126 mg) per day. At least 25% of the ascorbic acid was absorbed and excreted with the urine. On discontinuing ascorbic acid administration, oxalate excretion returned to baseline values within 24 h. The time-course of oxalate excretion revealed that following the 3rd dose of 2 g ascorbic acid a plateau in urinary oxalate excretion was reached (0.6 microgram ml-1 min-1) which was not exceeded despite additional 2-g doses of ascorbic acid. On termination of ascorbic acid administration the oxalate excretion rate remained at this level for a further 6 h and then decreased to prestudy rates. No effect of high-dose ascorbic acid ingestion was found on the daily urinary excretion of creatinine, uric acid, and inorganic phosphate. Calcium excretion was slightly reduced. In comparison to the large amounts of ascorbic acid ingested, the increase in urinary oxalate excretion as measured by isotachophoresis in these healthy male volunteers was very low, and is thus similar to the change in urinary content of oxalate which results from consuming normal diets.

This article has been cited by other articles:

				J. N Hathcock, A. Azzi, J. Blumberg, T. Bray, A. Dickinson, B. Frei, I. Jialal, C. S Johnston, F. J Kelly, K. Kraemer, et al. Vitamins E and C are safe across a broad range of intakes Am. J. Clinical Nutrition, April 1, 2005; 81(4): 736 - 745. [Abstract] [Full Text] [PDF]

				M. J. Gonzalez, J. R. Miranda-Massari, E. M. Mora, A. Guzman, N. H. Riordan, H. D. Riordan, J. J. Casciari, J. A. Jackson, and A. Roman-Franco Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later Integr Cancer Ther, March 1, 2005; 4(1): 32 - 44. [Abstract] [PDF]

				H. Tanaka, T. Matsuda, Y. Miyagantani, T. Yukioka, H. Matsuda, and S. Shimazaki Reduction of Resuscitation Fluid Volumes in Severely Burned Patients Using Ascorbic Acid Administration: A Randomized, Prospective Study Arch Surg, March 1, 2000; 135(3): 326 - 331. [Abstract] [Full Text] [PDF]

				J. A. Simon and E. S. Hudes Relation of Serum Ascorbic Acid to Serum Vitamin B12, Serum Ferritin, and Kidney Stones in US Adults Arch Intern Med, March 22, 1999; 159(6): 619 - 624. [Abstract] [Full Text] [PDF]