AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barton, J. C.
Right arrow Articles by Conrad, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barton, J. C.
Right arrow Articles by Conrad, M. E.
Agricola
Right arrow Articles by Barton, J. C.
Right arrow Articles by Conrad, M. E.

American Journal of Clinical Nutrition, Vol 34, 2192-2198, Copyright © 1981 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of phosphate on the absorption and retention of lead in the rat

JC Barton and ME Conrad

An inverse relationship between lead retention and dietary phosphate content has been known to exist for many years but the reasons for this association remained unknown. In rats, the manipulation of dietary phosphate content had no significant effect upon the absorption of lead from isolated gastrointestinal segments, but animals fed low phosphate content food had increased whole-body retention and bone deposition of intravenously administered tracer doses of radiolead. Intraluminal phosphate decreased the absorption of test doses of radiolead from the small intestine, possibly due to precipitation of lead in the gut lumen. Further, rats fed low phosphate diets absorbed increased quantities of an oral lead dose. Dietary phosphate deficiency may significantly increase body lead burdens by decreasing intraluminal lead precipitation and increasing lead retention, primarily in bone. Increased dietary phosphate, however, acts primarily to limit lead absorption.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by The American Society for Nutrition