AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Knodell, R. G.
Right arrow Articles by Wilson, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Knodell, R. G.
Right arrow Articles by Wilson, J. W.
Agricola
Right arrow Articles by Knodell, R. G.
Right arrow Articles by Wilson, J. W.

American Journal of Clinical Nutrition, Vol 34, 20-23, Copyright © 1981 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Vitamin C prophylaxis for posttransfusion hepatitis: lack of effect in a controlled trial

RG Knodell, MA Tate, BF Akl and JW Wilson

In vitro data suggest that vitamin C alters numerous parameters of immune function and might have potential as an agent which prevents infection. When an uncontrolled Japanese trial claimed efficacy of vitamin C in preventing posttransfusion hepatitis, a randomized double- blind controlled trial was initiated to determine if this claim of vitamin C efficacy could be confirmed. For 2 days before surgery and 2 wk after operation, cardiac surgery patients received orally either a lactose placebo or 800 mg of vitamin C four times daily. One hundred seventy-five patients completed the study. Highly significant elevations of plasma vitamin C were seen in the vitamin C treatment group as compared to the placebo group (p < 0.0005), but no significant difference in the incidence of posttransfusion hepatitis (p < 0.50) or the clinical course of hepatitis was seen between the two treatment groups.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
J. N Hathcock, A. Azzi, J. Blumberg, T. Bray, A. Dickinson, B. Frei, I. Jialal, C. S Johnston, F. J Kelly, K. Kraemer, et al.
Vitamins E and C are safe across a broad range of intakes
Am. J. Clinical Nutrition, April 1, 2005; 81(4): 736 - 745.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by The American Society for Nutrition