AJCN 19th International Congress of Nutrition
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American Journal of Clinical Nutrition, Vol 32, 6-9, Copyright © 1979 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of dietary composition on insulin receptors in normal subjects

JP Wigand, JH Anderson Jr, SS Jennings and WG Blackard

Six normal subjects were placed on a high carbohydrate diet (80%) and a high fat diet (60%) for 2 weeks each. Glucose tolerance testing with plasma immunoreactive insulin levels was performed along with insulin receptor quantitation after a control period and after each of the dietary manipulations. Despite improved carbohydrate tolerance and decreased plasma immuno-reactive insulin after the high carbohydrate diet (evidence for increased insulin sensitivity) insulin receptor number and affinity were unchanged. These studies suggest that the increased insulin sensitivity induced by a high carbohydrate diet is due to some adaptive change in postreceptor activity. Manipulations of dietary composition fail to alter insulin binding to peripheral mononuclear cells.


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E. J Parks and M. K Hellerstein
Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms1
Am. J. Clinical Nutrition, February 1, 2000; 71(2): 412 - 433.
[Abstract] [Full Text] [PDF]


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Copyright © 1979 by The American Society for Nutrition