| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 31, S33-S42, Copyright © 1978 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
WE Moore, EP Cato and LV Holdeman
Quantitative studies of the fecal flora of populations at different risk of colon cancer indicate that the relative proportions of some particular species of bacteria rather than of different genera of bacteria may be correlated with colon cancer incidence. Since the metabolic activity of different species in each genus varies widely, a shift in proportions of species could cause a major change in total metabolic activity in the individual. In samples taken from various areas of the intestinal tract and in scrapings from the intestinal wall, the composition of the flora remained relatively constant from the ascending colon to the rectum. Therefore, the bacteria in feces do reflect the flora of the large colon. The composition of the flora was not significantly affected by drastic changes in diet, but statistically significant shifts in the proportions of some species were noted in individuals under conditions of anger or fear stress. Although diet may not change the flora the individual maintains, the bacteria present may convert the different substrates provided by a high-fat diet as opposed to a high-fiber diet into metabolites that are potentially carcinogenic. The conversion of dietary components to carcinogenic compounds, identification of the bacteria capable of effecting such conversions, and the conditions favoring the proliferation of such bacteria will be investigated in greater detail.
This article has been cited by other articles:
|
|
 |
|
  D. J. Schlesinger, N. B. Shoemaker, and A. A. Salyers Possible Origins of CTnBST, a Conjugative Transposon Found Recently in a Human Colonic Bacteroides Strain Appl. Envir. Microbiol., July 1, 2007; 73(13): 4226 - 4233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Avila-Campos, C. Liu, Y. Song, M.-C. Rowlinson, and S. M. Finegold Determination of bft Gene Subtypes in Bacteroides fragilis Clinical Isolates J. Clin. Microbiol., April 1, 2007; 45(4): 1336 - 1338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bibiloni, M. Mangold, K. L. Madsen, R. N. Fedorak, and G. W. Tannock The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn's disease and ulcerative colitis patients. J. Med. Microbiol., August 1, 2006; 55(Pt 8): 1141 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chinda, S. Nakaji, S. Fukuda, J. Sakamoto, T. Shimoyama, T. Nakamura, T. Fujisawa, A. Terada, and K. Sugawara The Fermentation of Different Dietary Fibers Is Associated with Fecal Clostridia Levels in Men J. Nutr., August 1, 2004; 134(8): 1881 - 1886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Tannock, K. Munro, R. Bibiloni, M. A. Simon, P. Hargreaves, P. Gopal, H. Harmsen, and G. Welling Impact of Consumption of Oligosaccharide-Containing Biscuits on the Fecal Microbiota of Humans Appl. Envir. Microbiol., April 1, 2004; 70(4): 2129 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu and J. I. Gordon Inaugural Article: Honor thy symbionts PNAS, September 2, 2003; 100(18): 10452 - 10459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Cheng, N. Wesslund, N. B. Shoemaker, A. A. Salyers, and J. F. Gardner Development of an In Vitro Integration Assay for the Bacteroides Conjugative Transposon CTnDOT J. Bacteriol., September 1, 2002; 184(17): 4829 - 4837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Tannock, K. Munro, H. J. M. Harmsen, G. W. Welling, J. Smart, and P. K. Gopal Analysis of the Fecal Microflora of Human Subjects Consuming a Probiotic Product Containing Lactobacillus rhamnosus DR20 Appl. Envir. Microbiol., June 1, 2000; 66(6): 2578 - 2588. [Abstract] [Full Text]
|
|
|
|
|
|
A. Sghir, G. Gramet, A. Suau, V. Rochet, P. Pochart, and J. Dore Quantification of Bacterial Groups within Human Fecal Flora by Oligonucleotide Probe Hybridization Appl. Envir. Microbiol., May 1, 2000; 66(5): 2263 - 2266. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Rokosz, F. Meisel-Mikolajczyk, C. Malchar, M. Nowaczyk, and A. Gorski Polysaccharide and lipid components of Bacteroides thetaiotaomicron lipopolysaccharide as stimulators of endothelial adhesion molecule expression Innate Immunity, October 1, 1999; 5(5-6): 287 - 295. [Abstract] [PDF]
|
|
|
|
 |
|
 L Sanfilippo, T J Baldwin, M G Menozzi, S P Borriello, and Y R Mahida Heterogeneity in responses by primary adult human colonic epithelial cells to purified enterotoxin of Bacteroides fragilis Gut, November 1, 1998; 43(5): 651 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shetab, S. H. Cohen, T. Prindiville, Y. J. Tang, M. Cantrell, D. Rahmani, and J. Silva Jr. Detection of Bacteroides fragilis Enterotoxin Gene by PCR J. Clin. Microbiol., June 1, 1998; 36(6): 1729 - 1732. [Abstract] [Full Text]
|
|
|
|
|
|
M. M. Amann, M. J. Kullen, M. C. Martini, F. F. Busta, and L. J. Brady Consumption of Exogenous Bifidobacteria Does Not Alter Fecal Bifidobacteria and Breath Hydrogen Excretion in Humans J. Nutr., June 1, 1998; 128(6): 996 - 1002. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. S. Moncrief, A. J. Duncan, R. L. Wright, L. A. Barroso, and T. D. Wilkins Molecular Characterization of the Fragilysin Pathogenicity Islet of Enterotoxigenic Bacteroides fragilis Infect. Immun., April 1, 1998; 66(4): 1735 - 1739. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
