AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gibbs, J.
Right arrow Articles by Smith, G. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gibbs, J.
Right arrow Articles by Smith, G. P.
Agricola
Right arrow Articles by Gibbs, J.
Right arrow Articles by Smith, G. P.

American Journal of Clinical Nutrition, Vol 30, 758-761, Copyright © 1977 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Cholecystokinin and satiety in rats and rhesus monkeys

J Gibbs and GP Smith

When ingested food does not accumulate in the stomach or enter the small intestine, rats do not stop eating. Small amounts of food placed in the small intestine or intraperitoneal injections of the intestinal hormone cholecystokinin (CCK) elicit the full behavioral display of satiety in these sham-feeding rats. In rhesus monkeys, intravenous infusions of CCK produce large, dose-related reductions in meal size. In addition, gastric preloads of calorically trivial amounts of l- phenylalanine, but not d-phenylalanine, produce large reductions in meal size, suggesting that: 1) endogenous CCK acts as a "satiety signal," and 2) certain foods may be very efficient releasers of such a satiety signal. Whether the satiety effect of CCK is physiological in rats and monkeys or operates in humans has not been determined.


This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
P. K. Keel, B. E. Wolfe, R. A. Liddle, K. P. De Young, and D. C. Jimerson
Clinical Features and Physiological Response to a Test Meal in Purging Disorder and Bulimia Nervosa
Arch Gen Psychiatry, September 1, 2007; 64(9): 1058 - 1066.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. Huo, H. J. Grill, and C. Bjorbaek
Divergent Regulation of Proopiomelanocortin Neurons by Leptin in the Nucleus of the Solitary Tract and in the Arcuate Hypothalamic Nucleus
Diabetes, March 1, 2006; 55(3): 567 - 573.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. H. Peters, R. C. Ritter, and S. M. Simasko
Leptin and CCK modulate complementary background conductances to depolarize cultured nodose neurons
Am J Physiol Cell Physiol, February 1, 2006; 290(2): C427 - C432.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. C. Woods
Gastrointestinal Satiety Signals I. An overview of gastrointestinal signals that influence food intake
Am J Physiol Gastrointest Liver Physiol, January 1, 2004; 286(1): G7 - G13.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. M. Simasko and R. C. Ritter
Cholecystokinin activates both A- and C-type vagal afferent neurons
Am J Physiol Gastrointest Liver Physiol, December 1, 2003; 285(6): G1204 - G1213.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Murphy, C. N. Nunes, J. J. Ronan, M. Hanaway, A. M. Fairhurst, and T. N. Mellin
Centrally administered MTII affects feeding, drinking, temperature, and activity in the Sprague-Dawley rat
J Appl Physiol, July 1, 2000; 89(1): 273 - 282.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1977 by The American Society for Nutrition