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American Journal of Clinical Nutrition, Vol 3, 328-336, Copyright © 1955 by The American Society for Clinical Nutrition, Inc.
1 From the Department of Animal Husbandry and Nutrition, Alabama Polytechnic Institute, Auburn, Alabama
The pathological states observed in vitamin E deficiencies have been suggested to result from the action of lipid peroxides on sulfhydryl-sensitive enzyme systems. Vitamin E antagonists, such as unsaturated fat, o-cresyl esters, carbon tetrachloride, pyridine, sulfathiazole, sulfaguanidine, and sodium sulfite, may act as pro-oxidants. They promote the production of lipid peroxides in the body tissues, and thus increase the need for vitamin E.
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