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American Journal of Clinical Nutrition, Vol 3, 64-71, Copyright © 1955 by The American Society for Clinical Nutrition, Inc.
1 From the Department of Medicine, Medical College of Virginia, Richmond, Va.
Evidence gathered from the work of many investigators shows that 10 to 20 per cent of the fecal stercobilin excretion is closely related to erythrocyte and hemoglobin formation, rather than to erythrocyte destruction. This fraction is reduced when erythropoiesis is stimulated by hemorrhage in the normal man. The fraction is markedly increased in porphyria erythropoietica, but not in acute intermittent porphyria; it is also increased in pernicious anemia, but corrected in the latter by vitamin B12 therapy. The source of this stercobilin is not known, but it is perhaps related to the biosynthesis of the porphyrin ring from monopyrrole precursors.
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