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American Journal of Clinical Nutrition, Vol 29, 825-831, Copyright © 1976 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Lack of antiscorbutic activity of ascorbate 2-sulfate in the rhesus monkey

LJ Machlin, F Garcia, W Kuenzig, CB Richter, HE Spiegel and M Brin

Oral administration of 10 mg per kilogram of body weight of ascorbic acid (AA) completely prevented development of scurvy in juvenile rhesus monkey (Mucaca mulata) fed an AA-free liquid diet. The same dose cured scurvy when injected intramuscularly. An equimolar dose of ascorbic acid 2-sulfate (AA-2-S) did not prevent or cure scurvy. Neither AA nor AA-2-S altered serum cholesterol. AA but not AA-2-S reduced serum triglyceride. A case of scurvy in an AA-2-S treated monkey is described in detail.




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Copyright © 1976 by The American Society for Nutrition