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American Journal of Clinical Nutrition, Vol 29, 1300-1306, Copyright © 1976 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Morphological effects of vitamin D and its analogs on bone

SL Teitelbaum

Recent studies employing analogs of vitamin D in the treatment of clinical and experimental renal osteodystrophy indicate remarkable healing of morphological and biochemical skeletal lesions. After short periods of therapy, 25-hydroxycholecalciferol or 1,25- dihydroxycholecalciferol normalizes most of the histological abnormalities of the human uremic skeleton and significantly suppresses elevated levels of circulating immunoreactive parathyroid hormone. 25- Hydroxycholecalciferol appears to stimulate individual osteoblastic activity but does not increase the number of bone forming cells. Accumulated evidence suggests a direct effect of vitamin D and its metabolites on uremic bone.




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Copyright © 1976 by The American Society for Nutrition