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American Journal of Clinical Nutrition, Vol 27, 479-484, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Early changes in pyridoxine status of patients receiving isoniazid therapy

Bluebell R. Standal Ph.D.1, Stella M. Kao-Chen M.S.1, Goang-Yean Yang M.S.1, and Donald F. B. Char M.D.1

1 From the Department of Food and Nutritional Sciences, University of Hawaii, Honolulu, Hawaii 96822

EGPT, EGOT, and dietary intake of protein, niacin, and pyridoxine were measured in normal subjects and in tuberculosis patients who were treated with INH. EGOT measurements revealed vitamin B6 inadequacies, which EGPT measurements failed to uncover. Hospital and self-selected diets contained less than 2 mg pyridoxine, thus the daily dietary intake was below the Recommended Dietary Allowances. Subjects on self-selected diets had no vitamin B6 supplementation, and deficiency status was observed in normal subjects as well as in students who received low dosages of INH. The diet of tuberculosis patients in the hospital was supplemented daily with 50 mg vitamin B6 and, despite the high dosage of INH, these subjects were in optimum state of vitamin B6 nutriture. The protective effect of pyridoxine supplementation in hospitalized patients was present after the vitamin was withdrawn for 17 days.






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Copyright © 1974 by The American Society for Nutrition