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American Journal of Clinical Nutrition, Vol 27, 368-372, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Ascorbic acid concentrations in leukocytes and selected organs of guinea pigs in response to increasing ascorbic acid intake

M. O. Keith M.Sc.1 and O. Pelletier Ph.D.1

1 From the Food Research Laboratories, Health Protection Branch, National Health and Welfare, Tunney's Pasture, Ottawa, Ontario, Canada K1A 0L2

The concentration of ascorbic acid in leukocytes, adrenals, brain, spleen, and heart of growing male guinea pigs was investigated after the animals had received daily oral injections of l-ascorbic acid ranging from 0.2 to 10.0 mg/100 g body weight for 42 days while being maintained on an ascorbic acid-free semipurified diet. The concentration of ascorbic acid in leukocytes and organs increased most rapidly with increasing oral intake of the vitamin until the animals' requirement was reached. The dose-response curves were similar in shape for ascorbic acid in leukocytes and the organs, a similarity which was confirmed by high correlation coefficients. The results indicated that leukocytes reflect tissue concentration and hence vitamin C status in growing guinea pigs.






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Copyright © 1974 by The American Society for Nutrition