American Journal of Clinical Nutrition, Vol 27, 268-275, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Alteration of serum lipids in a group of free-living adult males

¹ From the Clayton Foundation Biochemical Institute and the Department of Home Economics, The University of Texas at Austin, Austin, Texas 78712

Fifty-eight married males at high risk of atherosclerotic heart disease, as indicated by the presence of elevated levels of serum cholesterol or triglyceride, or both, and of abnormal lipoprotein profiles on electrophoresis, completed a 3-month program stressing specific modifications in diet based on the diagnosis of type II. IIb. or IV hyperlipoproteinemia. The lipoprotein levels of these young males were particularly amenable to change despite the variation in adherence to the dietary modifications. A 19% reduction in serum cholesterol was achieved by all groups and a 57% decrease in triglyceride levels was achieved by the type IV group. The major modifications in intake of specific nutrients for the type II and IIb groups involved cholesterol, type and amount of fat, and calories; the major modification for the type IV group was in caloric intake, largely achieved by reduction in the consumption of simple carbohydrate.

The ultimate success of this project in reducing the incidence or the onset of atherosclerotic heart disease is still unknown, but the project was quite successful in achieving, in free-living males, highly significant changes in one prominent risk factor, hyperlipoproteinemia.