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American Journal of Clinical Nutrition, Vol 27, 1247-1253, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Biopterin content of human and rat fluids and tissues determined protozoologically

Herman Baker Ph.D.1, Oscar Frank Ph.D.1, Cyrus J. Bacchi Ph.D.1, and Seymour H. Hutner Ph.D.1

1 From the Departments of Medicine and Preventive Medicine, New Jersey Medical School, East Orange, New Jersey 07018 and Haskins Laboratories at Pace University, New York, New York

The ultrasensitive growth response to biopterin of the protozoan Crithidia fasciculata served to provide the ranges of biopterin levels in rat and human fluids and tissues. Eight patients with gout averaged 3.6 ng/ml as compared to 1.9 ng/ml for 31 normal subjects; 7 uremic patients averaged 8.1 ng/ml, and 6.2 ng/ml in 12 patients with alcoholic liver disease. The potential value of biopterin determinations in such diseases as well as parkinsonism and the carcinoid syndrome was noted.






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Copyright © 1974 by The American Society for Nutrition