AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Espinoza, J.
Right arrow Articles by Rosensweig, N. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Espinoza, J.
Right arrow Articles by Rosensweig, N. S.
Agricola
Right arrow Articles by Espinoza, J.
Right arrow Articles by Rosensweig, N. S.

American Journal of Clinical Nutrition, Vol 26, 608-611, Copyright © 1973 by The American Society for Clinical Nutrition, Inc.

Effect of aging on the, response of rat hepatic glycolytic enzyme activities to dietary sugars

Julio Espinoza M.D.1 and Norton S. Rosensweig M.D.1

1 From the Medical Service, St. Luke's Hospital Center and the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, N.Y.

The objective of the study was to investigate the effect of aging on the adaptive response of hepatic glycolytic enzyme activities to high carbohydrate diets. Nonfasted rats, ages 3, 8, or 52 weeks, were studied.

At all ages, 68%-glucose, fructose, or sucrose diets increased fructose-1-phosphate and fructose-1, 6-diphosphate aldolase and pyruvate kinase activities compared with a 40%-glucose (control) diet. For each enzyme, the greatest increase in enzyme activity occurred in 3-week-old rats, was somewhat less in the 8-week-old, and least in 52-week-old rats.

We conclude that hepatic glycolytic enzyme activities adapt to dietary sugars and that the adaptive response is blunted with aging.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1973 by The American Society for Nutrition