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American Journal of Clinical Nutrition, Vol 26, 403-408, Copyright © 1973 by The American Society for Clinical Nutrition, Inc.

Effect of cobalt, beer, and thiamin-deficient diets in pigs

Robert E. Burch M.D.1, Robert V. Williams B.S.1, and James F. Sullivan M.D.1

1 From the Department of Medicine, Creighton University School of Medicine and Veterans Administration Hospital, Omaha, Nebraska

The effects of cobalt, thiamin deficiency, beer, and various combinations of the three were studied in 32 pigs in an attempt to elucidate the mechanisms involved in the development of beer drinker's cardiomyopathy.

Cobalt supplementation is associated with detectable cobalt levels in blood and tissue. Tissue accumulation of cobalt is found in decreasing concentration in the liver, kidney, heart, and muscle.

All dietary regimens studied were associated with increased muscle zinc when compared with the control diet. Serum magnesium was lower than normal on all experimental diets.

Cobalt supplementation was associated with an increased ratio of heart weight to body weight. Cobalt as well as thiamin deficiency was associated with elevated serum enzymes, although microscopic evidence of tissue damage was not found. Thiamin deficiency and cobalt excess were not additive or synergistic in their effects on serum enzymes.

Cobalt is toxic to tissues, but other factors besides, or in addition to, beer and thiamin deficiency seem to be involved.






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Copyright © 1973 by The American Society for Nutrition