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American Journal of Clinical Nutrition, Vol 26, 397-402, Copyright © 1973 by The American Society for Clinical Nutrition, Inc.

Effect of aldosterone blockade during fasting and refeeding

Philip R. Boulter M.D1, Richard F. Spark M.D.1, and Ronald A. Arky M.D.1

1 From the Thorndike Memorial Laboratory, Harvard Medical Unit, Boston City Hospital, 818 Harrison Ave., Boston, Massachusetts 02118, and the Departments of Medicine, Beth Israel Hospital and the Harvard Medical School, Boston

The natriuresis of early starvation and the anti-natriuresis of carbohydrate refeeding is associated with changes in the distal tubular transport of sodium. To investigate the effect of mineralocorticoid activity on these phenomena, four obese healthy volunteers in sodium balance were studied during periods of fasting and refeeding under spironolactone-induced aldosterone blockade.

While receiving spironolactone, 1,200 mg/24 hr in divided doses, the four subjects underwent six studies consisting of equilibration, fasting, and refeeding periods on fixed sodium and potassium intake. The results demonstrate that aldosterone blockade will prevent the anti-natriuresis of refeeding. The role of aldosterone in the electrolyte changes induced by starvation and refeeding is discussed.






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Copyright © 1973 by The American Society for Nutrition