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American Journal of Clinical Nutrition, Vol 26, 161-164, Copyright © 1973 by The American Society for Clinical Nutrition, Inc.

Correlation of alcohol and tolbutamide blood clearance rates with microsomal alcohol-metabolizing enzyme activity

Michael E. Kostelnik M. D.1 and Frank L. Iber M.D.1

1 From the Division of Gastroenterology and Department of Medicine, Lemuel Shattuck Hospital, Jamaica Plain, Massachusetts 02130, and Tufts University School of Medicine, Medford, Massachusetts 02155

Alcohol and tolbutamide metabolism was followed serially in a group of recently drinking, noncirrhotic chronic alcoholics along with measurement of NADP-dependent ethanol-metabolizing activity in liver biopsies. Paired comparisons in eight patients over 6 weeks and in five patients over 10 weeks showed the expected slowing in rate of alcohol and tolbutamide degradation occurring in the shorted interval and a decrease in NADP-dependent ethanol-metabolizing activity over the longer interval. Slowing of ethanol and tolbutamide clearances while the measured enzyme activity remained at its original level may indicate that ethanol and tolbutamide blood clearance is unrelated to the NADP-dependent microsomal ethanol-oxidizing system.






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Copyright © 1973 by The American Society for Nutrition