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American Journal of Clinical Nutrition, Vol 25, 703-708, Copyright © 1972 by The American Society for Clinical Nutrition, Inc.

A double-tracer test of the oral absorption of 57Co- and 58Co-vitamin B12 using a whole-body monitor: clinical experience and technical factors

Maureen E. Mahaffy B.Sc., Keith Boddy B.Sc., M.Sc., Ph.D., F.Inst.P.1, and George Will B.Sc., M.B., Ch.B., F.R.C.P.G., M.R.C.P.E.2

1 Senior Lecturer (Health Physics and Nuclear Medicine), Scottish (Universities) Research Reactor Centre, East Kilbride, Glasgow, Scotland
2 Consultant Physician, Gateside Hospital, Greenock, Scotland

Clinical experience with a double-tracer test of the oral absorption of 58Co-vitamin B12 (free vitamin B12) and of 57Co-vitamin B12 with intrinsic factor (bound vitamin B12) is reported. Absorption of the free and bound vitamin was measured simultaneously using a whole-body monitor. Control subjects absorbed 19.6 to 84.9% of free vitamin B12 and the absorption ratio of bound/free in any subject did not exceed 2. In patients with pernicious anemia, the absorption of free vitamin B12 ranged from 0.3 to 16.2% and the absorption ratio in all patients was greater than 2. Technical sources of error are considered and examined; the errors are shown to be acceptable and the advantages of the test are outlined.






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Copyright © 1972 by The American Society for Nutrition