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American Journal of Clinical Nutrition, Vol 25, 302-310, Copyright © 1972 by The American Society for Clinical Nutrition, Inc.

Effects of tranylcypromine and l-cysteine on plasma amino acids in controls and schizophrenic patients

Jimmie M. Davis M.S.1, Joanne K. Spaide M.S.1, and Harold E. Himwich M.D.1

1 From the Thudichum Psychiatric Research Laboratory, Galesburg State Research Hospital, Galesburg, Illinois 61401

The effect of tranylcypromine and tranylcypromine plus cysteine loading on plasma amino acids of normal controls and schizophrenic patients was investigated. The study consisted of a control period, tranylcypromine loading, a tranylcypromine plus l-cysteine period, and a postmedication stage. The tranylcypromine loading increased the total amino acid in all normal controls except one and also in the two schizophrenic patients. The administration of l-cysteine with tranylcypromine was characterized by lower plasma amino acid levels for the seven subjects who had elevated amino acid concentrations during the tranylcypromine period. The normal control who showed lowered amino acid levels with tranylcypromine exhibited an increase when l-cysteine was given. The amino acid values were near baseline levels at the end of the postmedication period.




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P. J. Garlick
The Nature of Human Hazards Associated with Excessive Intake of Amino Acids
J. Nutr., June 1, 2004; 134(6): 1633S - 1639S.
[Abstract] [Full Text] [PDF]


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Copyright © 1972 by The American Society for Nutrition