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American Journal of Clinical Nutrition, Vol 25, 291-296, Copyright © 1972 by The American Society for Clinical Nutrition, Inc.
1 Chief, Nutrition Branch and Gnotobiotic Laboratory, Chemistry Division, U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver, Colorado 80240
2 Research Chemist, U. S. Public Health Service, Bureau of Occupational Health, Cincinnati, Ohio 45202
3 Chief, Chemistry Division, U. S. Army Medical Research and Nutrition Laboratory
1) Carotenoids in human tissues were in low and variable concentrations. Approximately 50% of the total carotenoids was present as carotene. The adrenal was the only tissue that consistently contained appreciable levels of carotenoids.
2) Tissue vitamin A concentration, except for liver, was approximately 1 µg/g wet tissue and was independent of liver vitamin A concentration.
3) Livers from 372 subjects from five geographic locations (Missouri, Iowa, Ohio, California, and Texas) were found to contain an average vitamin A concentration of 146 ± 151 µg/g of wet liver, a median value of 106 µg/g, and a range of 1 to 5,500 µg/g. Forty-seven subjects who died from accidental causes had an average of 107 ± 81 µg/g, median of 96 µg/g, and a range of 1 to 4,400 µg/g.
4) There was a large and significant regional difference in the average concentration of liver vitamin A and in the incidence of low (less than 40 µg/g) concentration levels. The overall incidence was 22%.
5) No correlation was found between the probable cause of death, socioeconomic status, or adipose pesticide concentration, and liver vitamin A stores. Liver samples from subjects who died from accidental causes tended to have less vitamin A than subjects who died from disease-related causes.
6) The liver vitamin A data reported in this study were in general agreement with other recent data from the United States and Canada that showed 20 to 30% of the populations tested were in the poor risk group regarding vitamin A nutriture.
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